Differential processing of their fl-subunit
نویسندگان
چکیده
The.platelet glycoprotein GPIIb/IIIa and the vitronectin receptor (VNR) are afl-heterodimeric proteins and share the same fl-subunit. By performing swainsonine treatment and digestion with endoglycosidase H (Endo H), we showed that the heavy chains of GPIIb and VNRa are glycosylated by complex-type oligosaccharide chains, and provided the first evidence for the presence of one complex carbohydrate residue on their light chains. The proteolytic cleavage of proGPIIb and the acquisition of Endo H-resistance are independent events occurring in the same Golgi compartment. We demonstrated the Endo H-sensitivity of GPIIIa and VNRfl in all cellular systems tested. In addition, this fl-subunit is differently glycosylated according to whether it is associated with GPIIb or VNRac, one carbohydrate chain being processed to the complex type on GPIIIa, but not on VNRfl.
منابع مشابه
fl-SUBUNIT OF SHEEP LUTROPIN By KAMBADUR MURALIDHAR and N. RAGHUVEER MOUDGAL
By using radioimmunoassay, the interaction of sheep lutropin (luteinizing hormone, LH) fl-subunit with rat ovarian receptors was investigated. The binding of fl-subunit was specific, although of much lower order than that of lutropin. Sheep lutropin fl-subunit effectively inhibited the binding ofhuman choriogonadotropin (chorionic gonadotropin, hCG) to the ovary, showing that both occupy the sa...
متن کاملStrategic Competence and Foreign Language test Performance in Iranian Context
A number of studies have accounted the integral role of foreign/second language learning and learner strategy use. However, a few of these studies have considered the relationships between strategic competence and its use and foreign language performance (FLP). This study applied structural equation modeling to deeply investigate the relationships between test takers’ strategy use and their per...
متن کاملStrategic Competence and Foreign Language test Performance in Iranian Context
A number of studies have accounted the integral role of foreign/second language learning and learner strategy use. However, a few of these studies have considered the relationships between strategic competence and its use and foreign language performance (FLP). This study applied structural equation modeling to deeply investigate the relationships between test takers’ strategy use and their per...
متن کاملPrimary Follicular Lymphoma of the Conjunctiva in a 12 Year-Old Male
Abstract Background Follicular lymphoma (FL) is the second most common adnexal lymphoma of the eye that almost all of them are reported in elderly patients. Primary FL of the eye has been reported in only two children. Pediatric FL appears to be biologically distinct from typical adult FL. In cases without other organ involvement excision alone with close monitoring is a treatment of choic...
متن کاملNew Impossible Differential Attacks of Reduced-Round Camellia-192 and Camellia-256
Camellia is a block cipher selected as a standard by ISO/IEC, which has been analyzed by a number of cryptanalysts. In this paper, we propose several 6-round impossible differential paths of Camellia with the FL/FL−1 layer in the middle of them. With the impossible differential and a well-organized precomputational table, impossible differential attacks on 10-round Camellia-192 and 11-round Cam...
متن کامل